ea0065p181 | Metabolism and Obesity | SFEBES2019
Fan Hei Man
, Bellafante Elena
, Mitchell Alice
, Ovadia Caroline
, Martineau Marcus
, Jones Peter
, McCance David
, Marschall Hanns-Ulrich
, Hunt Kate
, Bewick Gavin
, Bowe James
, Williamson Catherine
Serum concentrations of progesterone sulphates are raised in intrahepatic cholestasis of pregnancy (ICP), the commonest pregnancy-specific liver disease. Women with ICP have increased rates of gestational diabetes mellitus (GDM). We hypothesised that raised progesterone sulphates may modulate glucose homeostasis. Progesterone sulphates were assayed in serum samples from participants of the hyperglycaemia and adverse pregnancy outcomes (HAPO) study (n=7994), and ...